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Cuando se evalu el efecto de la liraglutida en combinacin con un ADO en el estudio LEAD 2 se observ que la combinacin de 1,8mg de la liraglutida ms la metformina disminuye en 1% la HbA1c en comparacin con la metformina sola y hubo similar control glicmico, mayor prdida de peso y menor ocurrencia de hipoglicemia en comparacin con la glimepirida56

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Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed-/random-effects models, with sensitivity, subgroup, and GRADE assessments

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