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Clinical Scenarios for IV Administration IV B12 is very helpful in some situations, like when the deficiency is severe and causing neurological problems, in cases of malabsorption like Crohns disease, or when taking pills doesnt work

For those with absorption issues, gastrointestinal conditions, or severe deficiencies, injections provide a fast, reliable, and efficient solution that oral supplements simply cannot match

Biochemistry 57 , 827838 (2018)

The HCG injections for fertility can be given either under the skin subcutaneously or into the buttocks intramuscularly depending on the doctors choice

Thats not to say vitamin B12 isnt important

The durability reflects structural changes (new mitochondria, upregulated AMPK signaling) rather than acute pharmacological effects