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The second type is Non-REM (NREM) sleep, which is characterized by a regular occurrence of local and global slow cortical oscillations, visible at the level of the EEG as slow waves, neurons in the cortex and thalamus are bistable

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The study follows a cautious, stepwise dose-escalation approach: starting from the maximum recommended starting dose and moving upward only after a thorough safety review at each level

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DOI: Published: Publisher Name: Springer, New York, NY Print ISBN: 978-1-4939-2189-8 Online ISBN: 978-1-4939-2190-4 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)