For example, in the STEP 4 trial, participants who stayed on semaglutide for 68 weeks lost an additional 7.9% of their body weight
Possible effects include: Loose or excess skin Fatigue Hair thinning Muscle loss (if not strength training) Gallbladder issues with rapid loss Nutrient deficiencies if diet is poor Most risks are reduced with gradual weight loss, adequate protein, strength training, and medical supervision
[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Tsai WH, Sung FC, Chiu LT, Shih YH, Tsai MC, Wu SI
Several widely used GLP-1 therapies, including Semaglutide and Tirzepatide, rely on pen injector systems to deliver medication accurately and safely
We cannot know yet, but the trajectory suggests Retatrutide has not revealed its ceiling
Orforglipron treatment led to a significant reduction in body weight compared with controls