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LUIGI FONTANA: Calorie restriction with optimal nutrition can prevent multiple chronic disease, cancer, diabetes, cardiovascular disease, less neurodegeneration, less sarcopenia, less frailty

Side effects have largely resolved, leaving appetite suppression as the primary ongoing effect

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Although NOX2 has been shown to enhance the pathogenesis in IAV infection through endosomal NOX2 oxidase-dependent ROS production, NOX4 oxidase exerts a protective effect against IAV infection 72

Promotes weight management

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