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As this study used open-source data without any identifiable personal information, it complies with ethical norms and moral requirements 35

As corroborated by upregulation of the proteasomal degradation pathway that is responsible for respirasome homeostasis, they likely indicate increased turnover of the respiratory machinery

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Glutathione neutralizes these free radicals before they can cause harm, helping maintain the integrity of the skin's moisture barrier

After intratracheal instillation in male Wistar rats, nickel oxide (Nio) NPs activated the NF-B pathway by upregulation of mRNA and protein expression of NF-B, an inhibitor of B kinase- and nuclear factor-inducing kinase, partially causing pulmonary damage (Chang et al., 2017)