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10.1016/j.abb.2016.04.014 58 CrossC

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Murto T, Skoog Svanberg A, Yngve A, et al

Intracellular signaling Bruton's tyrosine kinase (Btk) Btk is a B-cell receptor (BCR) associated kinase that activates the NFkB pathway ( Btk gene result in agammaglobulinemia ( Cereblon modulator (CC-220) CC-220 binds to cereblon (CRBN), a substrate receptor of CUL4 CRBN E3 ubiquitin ligase complex