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How the Evidence Balances Heart Rate Changes against Cardiovascular Outcomes While semaglutide raises resting heart rate mildly, several trials report cardiovascular event benefits for GLP-1 receptor agonists as a class in people with established cardiovascular disease

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has been a member of advisory boards or has consulted with AstraZeneca, Boehringer Ingelheim, Eli Lilly & Co., Fractyl, GlaxoSmithKline, Menarini/Berlin-Chemie, Merck, Sharp & Dohme and NovoNordisk

Clinically, we are seeing that some patients report a reduced sense of reward from certain behaviors

Native GLP-1 is degraded within 23 min in the circulation