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They are associated with good hemostatic properties and minimal bleeding, making them particularly suitable for patients receiving anticoagulation therapy or those with increased bleeding risk

(c) have echocardiographic evidence of advanced MVD consisting of characteristic valvular lesions of the mitral valve, regurgitation through the mitral valve (MR) on the color Doppler echocardiogram, and have echocardiographic evidence of left atrial and left ventricular dilatation

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