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A process for preparation of orlistat of Formula (I) comprising a) reacting formic acid with pivaloyl chloride in the presence of a base in a suitable solvent to prepare a stock solution of Pivaloyl Formic Anhydride (PFA)

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doi: 10.3389/fendo.2025.1614726 Received 19 April 2025 Accepted 24 September 2025 Published 13 October 2025 Volume 16 - 2025 Edited by Marcia Hiriart, Universidad Nacional Autonoma de Mexico, Mexico Reviewed by Absalon Gutierrez, University of Texas Health Science Center at Houston, United States Mubashshir Ali, University of South Florida, United States Updates Copyright 2025 Wang, Qi, Yang, Yang, Wang, Zhang, Cui, Wang, Wang and Lv

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