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Where Standard Dosing Begins In large randomized clinical trials, GLP-1 therapy begins at defined initiation thresholds before gradual titration upward

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Caplen, N

Most patients begin noticing reduced appetite within the first 12 weeks

Semaglutide is a GLP-1 agonist and works by increasing insulin release, lowering the amount of glucagon released, delaying gastric emptying, and reducing appetite