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Vegans, older adults, those with malabsorption conditions, and people taking metformin or proton pump inhibitors are at higher risk of B12 deficiency

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In addition, the GRAS or food additive status of a flavor intended for use in food is not relevant to other intended uses (e.g., inhalation). Basically, a company informs the FDA that it is compliant with the agencys regulations, but the FDA does not perform its own investigation into a companys purported ingredients in the GRAS notification process

3.van Walraven C, Austin P, Naylor CD

Established therapies should generally be considered first-line treatments unless contraindicated

Nutritional management of patients after bariatric surgery