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Improved Physical Performance: Low levels of B12 could result in poor physical performance and lead to weakness and fatigue

DOI: 10.1161/CIRCRESAHA.118.312498 PMC Review (2025) PMC12177089 Comprehensive mechanistic review confirming NAD+ as a critical coenzyme for mitochondrial function across de novo synthesis, Preiss-Handler, and salvage biosynthetic pathways

This causes a problem for those on a Vegan diet as it makes it more difficult for them to obtain it through their diet

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Lastly, vitamin B12 supplements are incredibly safe even in large doses

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