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Concomitantly with the development of resistance the up-regulation of a hydrogen-peroxide inducible GST was observed that might contribute to the elimination of cytotoxic reactive metabolites containing an electrophilic moiety (Shibu et al., 2012)

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N Engl J Med 2014;370:1383-92

Bilbault T, Taylor S, Walker R, Grundy SL, Pappert EJ, Agro A (2016) Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters

Most side effects remain manageable in the first 24 hours and typically worsen gradually through day 2 and 3

But his pace slowed, his knees started aching during longer runs, and workouts that once felt manageable suddenly felt exhausting