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Role of protein -SH groups in redox homeostasis--the erythrocyte as a model system

When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2

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However, these options can sometimes have more of an environmental impact due to a longer lifespan and greater methane gas emissions