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This integrative approach positions Arabidopsis not as a substitute for mammalian models, but as a complementary platform to dissect universal redox and signalling principles

MDHA reduction by a 12-oxo-phytodieonic acid reductase has also been documented (Maynard et al

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The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication