A Cochrane review supports the use of high-dose vitamin B 12 (1 mg and 2 mg daily) in elevating serum vitamin B 12 level and achieving haematological and neurological responses, even in patients with PA or with ileal resection.58 The recommendation for oral replacement is 1 mg daily for a month, and then 125 to 250 g daily as maintenance dose for patients with dietary insufficiency and food-cobalamin malabsorption, while for PA the maintenance dose is 1 mg daily.29 Vitamin B 12 does not have side-effects even when prescribed in large doses.59 However, hypokalaemia, resulting from uptake of circulating potassium by newly growing and dividing haematopoietic cells, can be severe or sometimes life-threatening
Impaired function in either organ can significantly prolong the half-life and active duration of peptides
Check ingredients for allergies and follow package directions
We assessed glycemic control, body weight and composition (with bio-impedance analysis), liver fibrosis and steatosis (with transient elastography)
Try anti-inflammatories like non-steroidal anti-inflammatory drugs (NSAIDs) as needed, and get plenty of omega-3 fatty acids
These steps help GLP-1 therapy work better and reduce problems like tiredness
