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The substrates, glutamate and glycine, are often present in cells, but some cells lack sufficient cysteine to make additional glutathione

Recommended Dosing Research suggests effective doses range from 100400 mg/day , depending on the intended outcome: Sleep : 200400 mg in the evening Cognition : 100200 mg with ~40100 mg caffeine (2:1 ratio) Stress and anxiety : 200400 mg spread across the day Individual responses vary, and like any supplement, L-theanine should be viewed as complementary to, not a substitute for, foundational lifestyle habits such as quality sleep, regular exercise, balanced nutrition, and effective stress management

Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding

doi: 10.1080/19490976.2024.2440111

Much of the literature is mechanistic