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Common Side Effects The most frequently reported side effects are gastrointestinal in nature and may include: Diarrhoea or loose stools Constipation Abdominal cramping or discomfort Bloating and flatulence Nausea These effects are typically mild to moderate and often diminish with continued use or dose reduction

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In a 2025 trial , people with obesity (and without diabetes) lost an average of 20.2% of their body weight on Zepbound, compared to 13.7% on Wegovy over 72 weeks

There's a reasonable narrative that it was actually Norvo Nordisk's focus and their time horizon that led to the decades long work to actually bear fruit

Fourman LT, Czerwonka N, Feldpausch MN, et al

Too little exercise and you miss out on this benefit, but overtraining without rest can actually deplete glutathione due to chronic oxidative strain