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Furthermore, emerging strategies, such as acetazolamide combined with remote ischemic preconditioning (RIPC), have shown additional risk reductions under controlled hypoxia exposure

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In the SURPASS-2 trial (N=1,879), tirzepatide 15 mg reduced HbA1c by 2.58% compared to 1.86% with semaglutide 1 mg at 40 weeks

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