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As of December 7, 2021, 2216 patients have been reported to use anti-TNF therapy alone, of which 2004 patients were rehabilitated without hospitalization, while 10 died with a mortality rate of 3.0.CO;2-L 27

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This suggests GLP-1 receptor activation in the brain may have secondary anti-inflammatory and thermoregulatory benefits independent of appetite suppression

66,67 Furthermore, oxidative stress disrupts mitochondrial membrane potential, impairs autophagy, and induces apoptosis, contributing to progressive liver damage

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