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2023;35(11):e14658

In one of the initial long-term pivotal studies of patients with type 1 and insulin-requiring T2D where full-dose pramlintide was added to existing insulin regimens in double-blind fashion without titration, it was observed that the severe hypoglycemia event rate during the first 4 weeks of therapy was higher in the pramlintide group compared with the placebo group

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GLP-1/GLP-1RAs have been shown to affect both basal and reward-related feeding, and increase dopamine transporter levels (202, 203)

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