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[1, 12, 13] In humans, oral rapamycin is often used in immunosuppressive protocols in transplant recipients to prevent organ rejection.[1416] In some cases, due to the mTOR pathways close association with insulin signaling, rapamycin treatment has resulted in derangements in glucose homeostasis.[17, 18] However, multiple studies have documented potential benefits of rapamycin treatment in the context of normative aging

[14] [4] This delayed transit time allows for improved glycemic control and enhanced satiety, contributing to weight loss

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10.1515/hsz-2018-0393 Biol

Their cardioprotective effects are similarly well established, with significant reductions in hospitalizations for heart failure and cardiovascular mortality, as evidenced in large trials like DAPA-CKD and EMPA-KIDNEY (166, 167)