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In preliminary results of OASIS 1, a recent 68-week, phase 3a clinical trial that compared once-daily oral semaglutide with placebo in adults with obesity or overweight with one or more underlying comorbidities, the average weight loss from baseline was 15.1% in the semaglutide group and 2.4% in the placebo group

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as highly effective anti-obesity therapies, producing weight loss of approximately 520% across clinical trials

Artificial sweeteners, especially sugar alcohols like sorbitol and xylitol, add to the osmotic load in the colon and worsen diarrhea

Is oral semaglutide as effective as injectable weight loss medication

JAMA 2021;325:1403-13.ArticlePubMed 32

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