is berberine a glp-1 receptor agonist as multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence | European Journal of Medical Research GLP-1 Supplement for Women &

The degradation of FPN, mediated by the E3 ubiquitin ligase RNF217, leads to intracellular iron accumulation, thereby increasing susceptibility to ferroptosis (Jiang et al., 2021)

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Moreover, LIRA significantly suppressed the expression of proinflammatory and profibrotic biomarkers, including NF-B, CD68, IL-1, TGF-1, osteopontin, and nitrotyrosine, in comparison to vehicle-treated rats [66]

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