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In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47

Ying S, Robinson DS, Meng Q, Rottman J, Kennedy R, Ringler DJ, et al

[DOI] [PubMed] [Google Scholar] 108.Krettek A, Sjoberg S

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However, how does hypertension lead to iron overload in the brain and what are specific mechanisms of ferroptosis in hypertensive brain injury are unknown