Relative to Day 1 fed animals, the average volume and number of DHS-3::GFP positive lipid droplets after a 24-h fast were reduced by 84% and 65%, respectively, as determined by fluorescence microscopy (Fig
A more recent study found that ghrelin inhibited GSIS in islets from non-T2D and T2D donors and that ghrelin mRNA expression and fasting circulating ghrelin levels were lower in T2D patients
Clinical Nutrition 35(4):842851
The same instrument showed a wide range of nausea or vomiting risk, from 5% to 78%
That figure is not unique to GLP-1 medications, some lean tissue loss accompanies most significant weight loss, but the pace and scale of GLP-1-driven weight loss makes the risk more acute
Patients with a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, or diabetic retinopathy (for those with diabetes) need individualised risk-benefit assessment