Hyperglycemia exacerbates mitochondrial electron transport chain (ETC) dysfunction and increases ROS production through advanced glycation end products and inflammatory pathways (Zhang et al., 2023
Consistent with these mechanisms, increasing preclinical evidence demonstrates that natural products can synergize with immune checkpoint inhibitors (ICIs) to overcome therapeutic resistance
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The Renin-Angiotensin-Aldosterone System (RAAS) It is well known that the RAAS is one of the most important regulators of arterial blood pressure, with a key role in cardiovascular and renal diseases, mainly mediated by inflammatory processes ( The cascade of the systemic RAAS starts with the liver angiotensinogen (AGT), which is converted to Angiotensin I (ANG I) by renin, a hormone secreted by the juxtaglomerular cells
Among the 81,617 participants who already had a substance use disorder, the researchers tracked serious health outcomes
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