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Conditions like gastroparesis , a disorder that affects stomach muscle function and delays stomach emptying, may worsen with GLP-1 use

This unique mechanism makes it one of the most promising compounds for comprehensive metabolic regulation, supporting blood sugar balance, appetite suppression, fat loss, and potential lean muscle preservation

A systematic review and meta-analysis of randomized clinical trial

Libido changes reported anecdotally are more likely attributable to indirect factors such as significant weight loss, hormonal shifts, fatigue, or psychological changes

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Some people lose less weight on semaglutide or tirzepatide than expected