JCO Precis Oncol 6:e2100547, 2022
Succinyladenosine accumulation has been reported in inborn errors of metabolism that disrupt purine metabolism and mitochondrial function, such as adenylosuccinate lyase (ADSL) deficiency and fumarase deficiency [49, 50], and its consistent upregulation in MMA may reflect secondary effects on nucleotide metabolism or mitochondrial energy balance, representing an underexplored aspect of MMA pathophysiology
Allow It to Absorb
Copper Exposure, Sensitivity, and Long-Term Safety Gaps Copper is biologically essential, but copper exposure is not automatically harmless, especially if a formulation changes systemic exposure or bypasses normal skin barriers
A study demonstrated that curcumin upregulates this miRNA, resulting in the suppression of PI3K/Akt signalling and a subsequent reduction in the proliferation rate of A549 cells (Jin et al., 2015)
Braun, M