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Mechanistic studies in cell and animal models of PD have demonstrated multiple neuroprotective actions of flavonoids (17)
Interpretation of the findings is difficult because data was only provided for the 'responder' subgroup and this did not include standard deviations or units for plasma GSH or GSH:GSSG, nor did it state whether the GSH values reported in Figure 4 of their paper represented tGSH or reduced glutathione
We are currently carrying out investigations to test this hypothesis
SIRT1 is a nicotinamide adenine dinucleotide ( NAD + )- dependent protein deacetylase that is involved in the cell-cycle regulation of ISCs and EEC progenitors
Glutathione (GSH) is an antioxidant produced in the body and found in foods and glutathione supplements
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