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Importantly, incubation with IsoK resulted in a 59% decrease in function compared with vehicle control (Figures 5c and d), with no change in Km (Figure 5e)

GLP 1 Agonists Semaglutide Aka: Wegovy, Ozempic Tirzepatide* Aka: Mounjaro, Zepbound * Adds a second pathway for maximal impact and efficacy

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Clinical trials have shown that tirzepatide can achieve greater average weight reduction, with one 72-week study reporting 20.2% loss versus 13.7% with semaglutide

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