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Ofatumumab, a fully human monoclonal antibody that targets CD20 + B cells, has demonstrated inhibitory effects on B lymphocyte activation (120)

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The treatment of ALC with doses of 2.253.0 g/day in patients with mild (initial) dementia caused by AD and vascular dementia (VD) led to a significant clinical improvement in patients with AD compared to in VD patients and placebo-treated patients [93]