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These cases focus on whether the drugs manufacturers adequately warned of the serious gastrointestinal risks now being listed on product labels

This was addressed pharmacologically by identifying PAMs, including BPAM and the plant lectin Concanavalin A (ConA), which slowed down desensitization to the timescale of seconds (Figure 9A)

A warm cup of coffee in the morning can trigger the gastrocolic reflex, which stimulates movement in the colon

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