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Lepore JJ, Olson E, Demopoulos L et al (2016) Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on cardiac function, cardiac metabolism, and exercise capacity in patients with chronic heart failure and reduced ejection fraction

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Conversely, in another phase 2b study involving patients with T2DM, tirzepatide showed significantly better efficacy in glucose control and weight loss compared to both placebo and dulaglutide, with an acceptable safety and tolerability profile (111)

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The severity of vomiting crises was subjectively evaluated by the parents