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doi: 10.1016/j.cmet.2005.02.005 52 MaSHensonESChenYGibsonSB

This severe depletion of GSH results in the synthesis of large amounts of -glutamylcysteine, which is increasingly converted to pyroglutamate when glycine is depleted, leading to metabolic acidosis

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For adults using standard oral glutathione, commonly used doses range from about 250mg to 500mg daily, generally recommended on an empty stomach

These molecular investigations shed light on the large human trials that have implicated antioxidants in cancer