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For example, high glucose levels were discovered to directly increase the expression levels of LOX and its subsequent enzymatic activation in the dermis or endothelial layer, which resulted in excessive crosslinking and disruption in the formation of collagen fibrils and hindered ECM integrity (80)

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On average, most people begin noticing positive effects within 2-4 weeks of consistent use

[DOI] [PubMed] [Google Scholar] 13.Mar Mar M, Morales A, Colell A, Garca-Ruiz C, Fernndez-Checa JC

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This structure stabilizes the complex and supports its role as a redox-inactive carrier of bioavailable copper (Pickart, Vasquez-Soltero, and Margolina 2012)