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They predominantly identified as female (67.4%) and were married (57.1%), and they were fairly equally distributed by age group between 18 and 60 years, with a smaller share aged 61 to 70 years

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In rodents, activation of AMPA receptors by the KET metabolite (2R,6R)-hydroxynorketamine has initially been thought essential to replicate KET antidepressant effects while administration of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX), an AMPA receptor antagonist, blocks KET effects (Zanos et al., 2016)