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Transcriptomic and proteomic analyses further highlight FOXO1 as a crucial link between glycolytic metabolism and macrophage polarization

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In addition, although a previous study reported increased levels of IFN- in in vitro PBMCs cultured with LBI 8,9 , in our study, serum IFN- levels were comparable among all groups (Figure S1C)

Our results indicate that treatments with 1 mM metformin and MS or MT modulate HG-HL-induced metabolic stress and partially alleviate the dysregulation of the cell cycle in the S-phase and G2-phase (Figure 2)