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This mobile redox active arm can transfer electrons to the incoming oxidized Trx or internally to the Grx domain (C28/C31) of the partner subunit where reduction of oxidized glutathione (GSSG) occurs

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ALC plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation in animals [15]

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The structure of the Mac2PAIP1M (middle domain of PAIP1) complex shows that Mac2 displays a typical // macrodomain fold, whereas PAIP1M adopts a HEAT repeat fold 70