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The 15 mg dose of tirzepatide produced a mean percent change in weight of almost 21% by week 72, which, when youre talking about a mean baseline body weight of 105.6 kg in that group, is a LOT of kgs dropped
Crucially, despite this variability, subsequent meta-analyses pooling the data from injectable GLP-1RAs have demonstrated a significant overall reduction in the risk of hospitalisation for HF with GLP-1RAs
Lyophilized (unmixed) powder is more stable: refrigerate for short-term use within 3-6 months
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N Engl J Med 377(12):11191131