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Pregnancy, hormonal contraception, hormone replacement therapy, and endocrine conditions can all activate melanocytes in UV-exposed zones
After consulting a large number of documents from PubMed, we have collated the metabolite markers in three diseases: T2DM, AD, and PCOS into tables (seen Supplementary Tables S24)
This in turn inhibits the transcription of mitochondrial ribosome-encoding genes and mitochondrial biogenesis, leading to cardiomyocyte apoptosis and cardiac fibrosis
NICE guidelines (NG28) recommend monitoring HbA1c every three to six months until stable, then six-monthly in patients with type 2 diabetes
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