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GLP-1 medications may be appropriate for adults with: BMI 30 kg/m BMI 27 kg/m with obesity-related conditions such as diabetes, hypertension, sleep apnea, or fatty liver disease Difficulty losing weight despite lifestyle changes Treatment suitability should always be determined by an endocrinologist after a comprehensive evaluation

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GCN2 phosphorylates eIF2, leading to ATF4 induction and upregulation of downstream targets including CHAC1