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38 Oral Route of Semaglutide The degradation of peptide-based drugs by proteolytic enzymes, the low permeability of intestinal epithelium and its mucus layer and the low pH of the gastrointestinal tract, are the major barriers preventing the oral administration of GLP-1RAs

This is advantageous for many peptide purifications, and drastically increases the possible method set-ups

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In Assay Guidance Manual (eds Markossian, S