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Dose adjustments should aim for the lowest appropriate dose to limit side effects and improve adherence

Figure 1 Biological Function of Lipoic Acid Quenching reactive oxygen species Based on the definition of an antioxidant provided by Halliwell and Gutteridge as being any substance that when present at low concentrations compared to those of an oxidizable substrate significantly delays or prevents oxidation of that substrate, LA has several unique characteristics among other natural antioxidants to fulfill this criterion (Petersen Shay et al., 2008)

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Later studies showed that the ratio of fusion protein (F) binding antibodies to neutralizing antibodies was higher in the sera of 36 vaccinated compared to 24 naturally infected children, suggesting that non-neutralizing antibodies to an abnormal F-protein conformation may have been a predisposing factor 27

Essentials of Medical Biochemistry

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