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In particular, the SST-secreting cell is the third most common cell type in the islets of Langerhans

A provider diagnoses PCOS when a woman meets two of the three Rotterdam criteria: Hyperandrogenism (high androgens based on lab tests or symptoms) Irregular or anovulatory menstrual cycles Signs of polycystic ovaries on ultrasound Elevated androgens (like DHEA and testosterone) are part of the diagnostic criteria, affecting 60 to 80% of women with PCOS

Despite their clinical significance in diagnosis, the specific cues that trigger this localized transition from fibrosis to nodularity remain a critical gap in the current literature

This leads to true hypertrophy through both increased muscle size and cell count

Cell Cycle 2010

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