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Most patients are surprised to learn that more is not always better

For weight management in people without diabetes , NICE recommends considering semaglutide 2.4 mg (Wegovy) for adults with a BMI 35 kg/m (or lower thresholds for certain ethnic groups) and at least one weight-related comorbidity

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Ultimately, GLP-1RAs enhance insulin excretion, leading to the inhibition of glucagon production by pancreatic -cells when blood sugar levels are high as well as a decrease of pancreatic -cell apoptosis and an increase in their proliferation