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This fundamental pharmacokinetic difference transforms a fleeting physiological signal into a powerful therapeutic agent approved by the FDA for type 2 diabetes management and chronic weight management

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24,25 In the general population, subclinical disease accounts for a large proportion of hypothyroidism, 19 with the prevalence ranging between 4% to 10%

In this study, we took an unbiased approach to unveil molecular partners working in concert with the GLP-1R to control -cell function, finding not only that the receptor engages with ER-endosome MCSs to organise its signalling, but that the main constituents of these inter-organelle contacts, namely the VAPs, are by a considerable margin the most prominent intracellular binding partners of active GLP-1R

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