Interestingly, introduction of carboxylic acid groups to RT slows down its reaction kinetics towards GSH comparing to RT-NH 2 and TQG-CN (Table 2), presumably due to the charge repulsion between the carboxylic acid groups and the anionic GSH
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Short NJ, Montalban-Bravo G, Alvarado Y, Konopleva M, Jabbour EJ, Garcia-Manero G, Yilmaz M, Jain N, Borthakur G, DiNardo CD, Daver N, Issa GC, Ohanian M, Pemmaraju N, Sasaki K, Maiti A, Chien KS, Ravandi F, Kadia TM, Andreeff M , Muftuoglu M, Delumpa R, Bose P, Pierce SA, Waller L, Banks G, Kantarjian H, and Cortes JE
and Dolan, V