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It is particularly important for the cells that line your intestines, known as enterocytes

doi: 10.1128/IAI.02368-14 78 PanZMaGKongLDuG

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Produced mainly in the liver in response to growth hormone released by the pituitary gland, IGF-1 acts as a powerful growth factor, promoting cell growth, differentiation, and survival throughout the body

This pattern suggests that oral bioavailability may vary significantly between individuals and that systemic effects require adequate absorption that not everyone achieves